Overview
Proper storage of your GLP-1 medication is essential — incorrect storage can reduce effectiveness or make the medication unsafe. The rules are similar across Ozempic, Wegovy, Mounjaro, and Zepbound, but there are important details to know.
The key principles are: keep unopened pens refrigerated, protect them from extreme temperatures, never freeze them, and use them before they expire. Once a pen is in use, most can be kept at room temperature for a limited time.
This guide covers storage at home, while traveling, and the specific requirements for each medication.
Storage Rules
Unopened pens
Store in the refrigerator at 36°F to 46°F (2°C to 8°C). Keep them in their original carton to protect from light. Don't freeze — if a pen freezes, don't use it.
Opened/In-use pens
Most GLP-1 pens can be kept at room temperature (59°F to 86°F) for up to 56 days after first use. Check your specific medication's instructions. Don't refrigerate pens that are in use.
Never freeze
Freezing destroys the medication. If your pen has been frozen (even if it thawed), don't use it. This is a common issue during travel or in very cold climates.
Protect from heat and light
Don't store pens in direct sunlight, in a hot car, or near heat sources. High temperatures degrade the medication.
Check expiration
Don't use pens past their expiration date. The medication may not be effective. Check the carton for the expiration date.
Inspect before use
The medication should be clear and colorless. If it's cloudy, discolored, or contains particles, don't use it.
Storage by Medication
| Medication | Refrigerator | Room Temp | Notes |
|---|---|---|---|
| Ozempic (semaglutide) | 36–46°F until first use | Up to 56 days at 59–86°F after first use | Can be stored in fridge or at room temp after first use. Don't freeze. |
| Wegovy (semaglutide) | 36–46°F until first use | Up to 28 days at 59–86°F after first use | Shorter room-temp window than Ozempic. Don't freeze. |
| Mounjaro (tirzepatide) | 36–46°F until first use | Up to 21 days at 59–86°F after first use | Can be stored in fridge or at room temp after first use. Don't freeze. |
| Zepbound (tirzepatide) | 36–46°F until first use | Up to 21 days at 59–86°F after first use | Same as Mounjaro. Don't freeze. |
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